Mouse Models of Colorectal and Intestinal Cancer Jesse Russell

ISBN: 9785511797960

Published: April 8th 2012

Paperback

162 pages


Description

Mouse Models of Colorectal and Intestinal Cancer  by  Jesse Russell

Mouse Models of Colorectal and Intestinal Cancer by Jesse Russell
April 8th 2012 | Paperback | PDF, EPUB, FB2, DjVu, talking book, mp3, ZIP | 162 pages | ISBN: 9785511797960 | 10.74 Mb

High Quality Content by WIKIPEDIA articles! Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated or challenged with chemicals to develop malignancies in the gastrointestinal tract.MoreHigh Quality Content by WIKIPEDIA articles!

Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated or challenged with chemicals to develop malignancies in the gastrointestinal tract. These models enable researchers to study the onset, progression of the disease, and understand in depth the molecular events that contribute to the development and spread of colorectal cancer. They also provide a valuable biological system, to simulate human physiological conditions, suitable for testing therapeutics that can potentially benefit patients.

An important example is the development of the APC mutant mouse model of colorectal cancer and the subsequent observation that cyclooxygenase expression is an early event in colorectal carcinogenesis. Genetic disruption of the cyclooxygenase-2 (COX-2) gene or inhibition of the activity of COX-2 with chemical inhibitors reduced the polyp burden in mice. These observations gave rationale to treat human patients suffering from the familial form of the disease FAP with specific COX-2 inhibitors.



Enter the sum





Related Archive Books

  1. 21.01.2015Polytopes, Rings, and K-Theory
  2. 05.10.2011Guilty!
  3. 17.02.2011Dialects


Related Books


Comments

Comments for "Mouse Models of Colorectal and Intestinal Cancer":


laxicoia.com

©2011-2015 | DMCA | Contact us